He aha nā Biofilms?

Ma nā moʻomanaʻo a me nā wikiō ma mua, ua kamaʻilio nui mākou e pili ana i nā biofilms bacteria a i ʻole biofilms plaque, akā he aha ke ʻano o nā biofilms a pehea e hana ai?

ʻO ke kumu, ʻo nā biofilms he nui nui o nā huakini a me nā haʻiki e pili ana i kahi ʻili ma o kahi mea like me ke kāpili e hana ma ke ʻano he heleuma a hāʻawi i ka pale mai ke kaiapuni.ʻO kēia ka mea e hiki ai i nā hua bacteria a me nā haʻiki i hoʻopaʻa ʻia i loko e ulu ma ka ʻaoʻao a me ke kūpaʻa.Hoʻopili pū ʻia nā microorganism ʻē aʻe e pili ana i kēia ʻano paʻa i loko o ke kiʻiʻoniʻoni e hana ana i nā biofilms o nā ʻano bacteria a me nā ʻano haʻi i hui pū ʻia a lilo i mau haneli a mau haneli mau papa mānoanoa.He mea paʻakikī loa ka mālama ʻana i kēia mau biofilms no ka mea ʻaʻole hiki i nā antimicrobials a me nā mea hoʻokipa hoʻokipa ke komo maʻalahi i loko o kēia mau kiʻiʻoniʻoni e kūʻē i kēia mau meaola i ka nui o nā lāʻau lapaʻau.

He mea maikaʻi loa nā biofilms e hoʻoikaika lākou i ka ʻae ʻana i ka lāʻau antibiotic ma o ka pale kino ʻana i nā germs.Hiki iā lākou ke hana i ka maʻi bacteria a hiki i ka 1,000 mau manawa ʻoi aku ka pale ʻana i nā lāʻau antibiotic, disinfectants a me ka ʻōnaehana immune host a ʻike ʻia e nā ʻepekema he nui kekahi o nā kumu nui o ka pale ʻana i ka lāʻau antibiotic ma ka honua holoʻokoʻa.

Hiki ke hana ʻia nā biofilms ma nā wahi ola a me nā mea ola ʻole e like me nā niho (plaque a me ka tartar), ka ʻili (e like me nā ʻeha a me ka seborrheic dermatitis), nā pepeiao (otitis), nā mea lapaʻau (e like me nā catheters a me nā endoscopes), nā lumi kuke a me nā countertops, nā meaʻai a me nā meaʻai. nā lako hana, nā ʻili o ka haukapila, nā paipu a me nā kānana i loko o nā mea kanu mālama wai a me nā keʻena hoʻomalu kaʻina hana ʻaila.

Pehea ka hana ʻana o nā biofilms?

Aia mau nā hua bacteria a me nā haʻakai i loko o ka waha a ke hoʻāʻo mau nei lākou e hoʻopololei i ka ʻili o nā niho me ka paʻa paʻa o ka mea like me ke kāpili i ʻōlelo ʻia ma luna.(ʻO nā hōkū ʻulaʻula a me ka uliuli ma kēia kiʻi e hōʻike ana i ka bacteria a me nā haʻi.)

Pono kēia mau maʻi bacteria a me nā haʻani i kahi kumu meaʻai e kōkua ai i ka ulu a me ka paʻa o ka membrane.Loaʻa kēia mai nā ion metala i loaʻa maoli i ka waha e like me ka hao, ka calcium a me ka magnesium, a me nā mea ʻē aʻe.(Ke hōʻike nei nā kiko ʻōmaʻomaʻo ma ke kiʻi i kēia mau ion metala.)

Hoʻohui ʻia nā maʻi bacteria ʻē aʻe i kēia wahi e hana i nā micro-colonies, a ke hoʻomau nei lākou i ka hoʻokuʻu ʻana i kēia mea paʻa ma ke ʻano he papa pale e like me ka dome e hiki ai ke hāʻawi i ka pale mai ka ʻōnaehana immune host, antimicrobials a me nā disinfectants.(Ke hōʻike nei nā hōkū poni i ke kiʻi i nā ʻano bacteria ʻē aʻe a ʻo ka papa ʻōmaʻomaʻo e hōʻike ana i ke kūkulu ʻana o ka matrix biofilm.)

Ma lalo o kēia biofilm paʻa, hoʻonui wikiwiki ka bacteria a me nā haʻiki e hana i kahi 3-dimensional, multi-layered cluster a i ʻole i kapa ʻia ʻo ka plaque niho, he biofilm mānoanoa nā haneli a me nā haneli mau papa hohonu.Ke hiki ka biofilm i ka nui koʻikoʻi, hoʻokuʻu ʻo ia i kekahi mau hua bacteria e hoʻomaka i kēia kaʻina hana colonization ma nā ʻili niho paʻakikī ʻē aʻe e holomua ana i ka hana ʻana o ka plaque i nā ʻili niho āpau.(Ke hōʻike nei ka papa ʻōmaʻomaʻo ma ke kiʻi i ka mānoanoa o ka biofilm a ulu aʻe ka niho.)

I ka hopena, e hoʻomaka ana nā biofilms plaque, i hui pū ʻia me nā minerale ʻē aʻe i loko o ka waha e calcify, e hoʻohuli iā lākou i mea paʻakikī loa, ʻāʻī, ʻano iwi i kapa ʻia ʻo calculus, a i ʻole tartar.(Hōʻike ʻia kēia ma ke kiʻi e ka hale kiʻiʻoniʻoni melemele ma ka ʻaoʻao o lalo o nā niho.)

Ke hoʻomau nei ka bacteria i ke kūkulu ʻana i nā papa o ka plaque a me ka tartar i loaʻa ma lalo o ka ʻāʻī.ʻO kēia, i hui pū ʻia me nā hale helu ʻoi aʻe, hoʻonāukiuki a ʻokiʻoki i nā ʻāʻī ma lalo o ka gumline e hiki ai ke hoʻoulu i ka periodontitis.Inā haʻalele ʻole ʻia, hiki iā ia ke kōkua i nā maʻi ʻōnaehana e hoʻopilikia ana i ka puʻuwai o kāu pipi, ate a me nā puʻupaʻa.(ʻO ka papa kiʻiʻoniʻoni melemele ma ke kiʻi e hōʻike ana i ka biofilm plaque holoʻokoʻa e lilo ana i calcified a e ulu ana ma lalo o ka gumline.)

Wahi a ka National Institute of Health (NIH, USA), ma kahi o 80% o nā maʻi bacterial kanaka ke kumu mai nā biofilms.

Hoʻolaha ʻo Kane Biotech i ka holomua o nā ʻenehana a me nā huahana e wāwahi i nā biofilms a luku i ka bacteria.ʻO ka luku ʻana i nā biofilms e ʻae i ka hoʻohaʻahaʻa nui ʻana i ka hoʻohana ʻana i nā antimicrobials a pēlā e komo ai i kahi hoʻohana maʻalahi a ʻoi aku ka maikaʻi o kēia mau mea lapaʻau.

ʻO nā ʻenehana i hoʻomohala ʻia e Kane Biotech no ka bluestem a me ka silkstem he hopena maikaʻi i ke olakino kanaka, holoholona a me ke kaiapuni.